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Assay Detail

CHEMBL771559

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Increased percentage of formazan production in drug treated virus infected cells to equal 50% of control drug free uninfected cells on serotype 14
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Ford CE, Meador JW, Ferre RA, Worland ST.
J Med Chem (1999) 42 : 1203 -1212
PubMed 10197964 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 6.99 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19888 1 8.22
CHEMBL417823 1 7.70
CHEMBL19825 1 7.70
CHEMBL279272 1 7.30
CHEMBL280113 1 7.30
CHEMBL19334 1 6.80
CHEMBL279889 1 6.72
CHEMBL281565 1 6.72
CHEMBL19333 1 6.55
CHEMBL19911 1 6.44
CHEMBL19648 1 6.27
CHEMBL20174 1 6.17
CHEMBL281395 1 -
CHEMBL19463 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19888 EC50 = 6.0 nM 8.22
CHEMBL417823 EC50 = 20.0 nM 7.70
CHEMBL19825 EC50 = 20.0 nM 7.70
CHEMBL279272 EC50 = 50.0 nM 7.30
CHEMBL280113 EC50 = 50.0 nM 7.30
CHEMBL19334 EC50 = 160.0 nM 6.80
CHEMBL279889 EC50 = 190.0 nM 6.72
CHEMBL281565 EC50 = 190.0 nM 6.72
CHEMBL19333 EC50 = 280.0 nM 6.55
CHEMBL19911 EC50 = 360.0 nM 6.44
CHEMBL19648 EC50 = 540.0 nM 6.27
CHEMBL20174 EC50 = 680.0 nM 6.17
CHEMBL281395 EC50 140.0 nM -
CHEMBL19463 EC50 480.0 nM -