Assay Detail
Functional
CHEMBL771560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increased percentage of formazan production in drug treated virus infected cells to equal 50% control drug free uninfected cells on serotype 14
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human rhinovirus sp. |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.08 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279448 | — | — | 1 | 9.00 |
| CHEMBL20210 | RUPINTRIVIR | 2.0 | 1 | 8.30 |
| CHEMBL20636 | — | — | 1 | 8.00 |
| CHEMBL21082 | — | — | 1 | 8.00 |
| CHEMBL20260 | — | — | 1 | 7.70 |
| CHEMBL277897 | — | — | 1 | 7.52 |
| CHEMBL277716 | — | — | 1 | 7.52 |
| CHEMBL19648 | — | — | 1 | 6.27 |
| CHEMBL20239 | — | — | 1 | 6.22 |
| CHEMBL281163 | — | — | 1 | 5.80 |
| CHEMBL20668 | — | — | 1 | 5.40 |
| CHEMBL20259 | — | — | 1 | 5.25 |
| CHEMBL280938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279448 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL20210 | RUPINTRIVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL20636 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL21082 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL20260 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL277897 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL277716 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL19648 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL20239 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL281163 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL20668 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL20259 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL280938 | — | EC50 | 100.0 | nM | - |