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Assay Detail

CHEMBL771612

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory activity against Adenosine diphosphate (ADP) induced rabbit platelet aggregation
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2(1H)-quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities.
Koga Y, Kihara Y, Okada M, Inoue Y, Tochizawa S, Toga K, Tachibana K, Kimura Y, Nishi T, Hidaka H.
Bioorg Med Chem Lett (1998) 8 : 1471 -1476
PubMed 9873372 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.79 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35187 1 7.10
CHEMBL284074 1 6.92
CHEMBL36398 1 6.72
CHEMBL37778 1 6.57
CHEMBL34290 1 6.15
CHEMBL35247 1 5.66
CHEMBL284838 K-134 2.0 2 5.64
CHEMBL32617 1 5.64
CHEMBL34431 CILOSTAMIDE 2.0 1 5.62
CHEMBL286826 1 5.62
CHEMBL286919 1 5.60
CHEMBL38238 1 5.58
CHEMBL34347 1 5.52
CHEMBL432471 1 5.42
CHEMBL35246 1 5.41
CHEMBL287603 1 4.82
CHEMBL799 CILOSTAZOL 4.0 1 4.54
CHEMBL25 ASPIRIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35187 IC50 = 80.0 nM 7.10
CHEMBL284074 IC50 = 120.0 nM 6.92
CHEMBL36398 IC50 = 190.0 nM 6.72
CHEMBL37778 IC50 = 270.0 nM 6.57
CHEMBL34290 IC50 = 710.0 nM 6.15
CHEMBL35247 IC50 = 2200.0 nM 5.66
CHEMBL284838 K-134 IC50 = 2300.0 nM 5.64
CHEMBL32617 IC50 = 2300.0 nM 5.64
CHEMBL34431 CILOSTAMIDE IC50 = 2400.0 nM 5.62
CHEMBL286826 IC50 = 2400.0 nM 5.62
CHEMBL286919 IC50 = 2500.0 nM 5.60
CHEMBL284838 K-134 IC50 = 2500.0 nM 5.60
CHEMBL38238 IC50 = 2600.0 nM 5.58
CHEMBL34347 IC50 = 3000.0 nM 5.52
CHEMBL432471 IC50 = 3800.0 nM 5.42
CHEMBL35246 IC50 = 3900.0 nM 5.41
CHEMBL287603 IC50 = 15000.0 nM 4.82
CHEMBL799 CILOSTAZOL IC50 = 29000.0 nM 4.54
CHEMBL25 ASPIRIN IC50 > 1000000.0 nM -