Compound Detail
CHEMBL284838
K-134 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL284838 |
| Name | K-134 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ULGNGSQNNMKROG-WOJBJXKFSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
14
Publications
2
Known Names
1
Indications
1
Mechanisms
Molecular Properties
399.5
MW (Da)
2.77
ALogP
4
HBA
3
HBD
94.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Phosphodiesterase 3 inhibitor | INHIBITOR | Phosphodiesterase 3 | ✓ | ✓ |
Indications
Intermittent Claudication
Activity Summary
IC50 4 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oryctolagus cuniculus CHEMBL374 | IC50 | 5.66 | 5.585 | 2200.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.64 | 5.62 | 2300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | IC50 | = | 2200.0 | nM | 5.66 | In vitro inhibitory activity against collagen induced rabbit platelet aggregatio... | 9873372 |
| Unchecked | IC50 | = | 2300.0 | nM | 5.64 | In vitro inhibitory activity against Adenosine diphosphate (ADP) induced rabbit ... | 9873372 |
| Unchecked | IC50 | = | 2500.0 | nM | 5.6 | In vitro inhibitory activity against Adenosine diphosphate (ADP) induced rabbit ... | 9873372 |
| Oryctolagus cuniculus | IC50 | = | 3100.0 | nM | 5.51 | In vitro inhibitory activity against collagen induced rabbit platelet aggregatio... | 9873372 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873372 | 10.1016/s0960-894x(98)00246-7 | Mus musculus | 3 |
| 9873372 | 10.1016/s0960-894x(98)00246-7 | Rattus norvegicus | 3 |
| 9873372 | 10.1016/s0960-894x(98)00246-7 | Unchecked | 2 |
| 9873372 | 10.1016/s0960-894x(98)00246-7 | Oryctolagus cuniculus | 2 |
| - | 10.6019/CHEMBL5724796 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5724796 | Cyclin-dependent kinase 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5724796 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5724796 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5724796 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5724796 | Fibroblast growth factor receptor 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Peregrin | 1 |
| - | 10.6019/CHEMBL5724796 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5724796 | Bromodomain-containing protein 4 | 1 |
Data from ChEMBL 36 via Core Engine