Assay Detail
Binding
CHEMBL771785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.54 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136198 | — | — | 1 | 7.92 |
| CHEMBL423723 | — | — | 1 | 7.89 |
| CHEMBL138877 | — | — | 2 | 7.80 |
| CHEMBL337372 | — | — | 1 | 7.50 |
| CHEMBL138935 | — | — | 1 | 7.30 |
| CHEMBL421919 | — | — | 1 | 7.12 |
| CHEMBL139207 | — | — | 1 | 7.10 |
| CHEMBL136755 | — | — | 1 | 6.96 |
| CHEMBL343953 | — | — | 1 | 6.70 |
| CHEMBL342904 | — | — | 1 | 6.51 |
| CHEMBL138783 | — | — | 1 | 6.41 |
| CHEMBL424479 | — | — | 1 | 6.30 |
| CHEMBL134916 | — | — | 1 | 6.21 |
| CHEMBL136876 | — | — | 1 | 6.19 |
| CHEMBL136076 | — | — | 1 | 5.85 |
| CHEMBL136216 | — | — | 1 | 5.77 |
| CHEMBL136082 | — | — | 1 | 5.55 |
| CHEMBL344825 | — | — | 1 | 5.13 |
| CHEMBL344239 | — | — | 1 | 4.85 |
| CHEMBL137562 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136198 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL423723 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL138877 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL138877 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL337372 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL138935 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL421919 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL139207 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL136755 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL343953 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL342904 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL138783 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL424479 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL134916 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL136876 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL136076 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL136216 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL136082 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL344825 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL344239 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL137562 | — | IC50 | = | 27000.0 | nM | 4.57 |