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Assay Detail

CHEMBL771794

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against HRV-14 3C protease.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Webber SE, Okano K, Little TL, Reich SH, Xin Y, Fuhrman SA, Matthews DA, Love RA, Hendrickson TF, Patick AK, Meador JW, Ferre RA, Brown EL, Ford CE, Binford SL, Worland ST.
J Med Chem (1998) 41 : 2786 -2805
PubMed 9667969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 7.35 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96185 1 8.30
CHEMBL419332 1 8.30
CHEMBL96803 1 8.30
CHEMBL95007 1 8.22
CHEMBL95003 1 8.15
CHEMBL97601 1 8.00
CHEMBL94652 1 7.92
CHEMBL95031 1 7.75
CHEMBL329857 1 7.40
CHEMBL96975 1 7.28
CHEMBL328212 1 7.18
CHEMBL95120 1 7.14
CHEMBL327370 1 6.88
CHEMBL94600 1 6.84
CHEMBL97090 1 6.72
CHEMBL428180 1 6.33
CHEMBL97497 1 6.19
CHEMBL95173 1 5.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96185 Ki = 5.0 nM 8.30
CHEMBL419332 Ki = 5.0 nM 8.30
CHEMBL96803 Ki = 5.0 nM 8.30
CHEMBL95007 Ki = 6.0 nM 8.22
CHEMBL95003 Ki = 7.0 nM 8.15
CHEMBL97601 Ki = 10.0 nM 8.00
CHEMBL94652 Ki = 12.0 nM 7.92
CHEMBL95031 Ki = 18.0 nM 7.75
CHEMBL329857 Ki = 40.0 nM 7.40
CHEMBL96975 Ki = 52.0 nM 7.28
CHEMBL328212 Ki = 66.0 nM 7.18
CHEMBL95120 Ki = 73.0 nM 7.14
CHEMBL327370 Ki = 132.0 nM 6.88
CHEMBL94600 Ki = 146.0 nM 6.84
CHEMBL97090 Ki = 190.0 nM 6.72
CHEMBL428180 Ki = 469.0 nM 6.33
CHEMBL97497 Ki = 640.0 nM 6.19
CHEMBL95173 Ki = 3600.0 nM 5.44