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Assay Detail

CHEMBL771798

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Catalytic rate constant (Kobs/[I]) was evaluated against human rhinovirus (HRV) serotype 14 3C Protease (3CP)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human rhinovirus sp.
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Reich SH, Prins TJ, Marakovits JT, Littlefield ES, Zhou R, Tikhe J, Ford CE, Wallace MB, Meador JW, Ferre RA, Brown EL, Binford SL, Harr JE, DeLisle DM, Worland ST.
J Med Chem (1998) 41 : 2806 -2818
PubMed 9667970 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.52 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94688 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94688 Ki = 30.0 nM 7.52