Assay Detail
Binding
CHEMBL772072
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Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase C (alpha)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol (DAG). 4. Interaction of -alkylidene--lactones with protein kinase C (PK-C)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.44 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422215 | — | — | 1 | 6.70 |
| CHEMBL13306 | — | — | 1 | 6.52 |
| CHEMBL12988 | — | — | 1 | 6.30 |
| CHEMBL13221 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422215 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL13306 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL12988 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL13221 | — | Ki | = | 600.0 | nM | 6.22 |