Assay Detail
Functional
CHEMBL772218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for cytotoxicity against RG-2 (Rat) Glioma cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.64 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.82 |
| CHEMBL49378 | — | — | 1 | 4.46 |
| CHEMBL286346 | RO-54864 | — | 1 | - |
| CHEMBL523 | NORDAZEPAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL49378 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL286346 | RO-54864 | IC50 | > | 100000.0 | nM | - |
| CHEMBL523 | NORDAZEPAM | IC50 | > | 200000.0 | nM | - |