Compound Detail
CHEMBL523
NORDAZEPAM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL523 |
| Name | NORDAZEPAM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | AKPLHCDWDRPJGD-UHFFFAOYSA-N |
1
Targets
7
Activities
2
Assay Types
8
PK Parameters
20
Publications
15
Known Names
1
Indications
Molecular Properties
270.7
MW (Da)
3.13
ALogP
2
HBA
1
HBD
41.5
PSA (Ų)
0.85
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Anxiety
ATC Classification
N05BA16
nordazepam
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS
Activity Summary
IC50 6 meas.
Ki 1 meas. best 4.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL2094133 | Ki | 4.14 | 4.14 | 73000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.12 | mL.min-1.kg-1 | Homo sapiens |
| F | 80.0 | % | Homo sapiens |
| F | 99.0 | % | Homo sapiens |
| Fu | 0.03 | - | Homo sapiens |
| Fu | 0.03 | - | Homo sapiens |
| MRT | 63.0 | hr | Homo sapiens |
| T1/2 | 46.0 | hr | Homo sapiens |
| T1/2 | 50.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 73000.0 | nM | 4.14 | Binding affinity for umolar GABA-A central benzodiazepine receptor | 6330354 |
Literature References
Data from ChEMBL 36 via Core Engine