Assay Detail
Functional
CHEMBL772348
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In vitro inhibition of PAF induced aggregation of rabbit platelets.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.48 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158974 | — | — | 1 | 8.68 |
| CHEMBL421843 | — | — | 1 | 8.39 |
| CHEMBL419779 | — | — | 1 | 8.07 |
| CHEMBL351410 | — | — | 1 | 8.01 |
| CHEMBL158384 | — | — | 1 | 7.96 |
| CHEMBL274420 | CV-6209 | — | 1 | 7.92 |
| CHEMBL161096 | — | — | 1 | 7.89 |
| CHEMBL160995 | — | — | 1 | 7.82 |
| CHEMBL161597 | — | — | 1 | 7.82 |
| CHEMBL157989 | — | — | 1 | 7.80 |
| CHEMBL290840 | — | — | 1 | 7.68 |
| CHEMBL161127 | — | — | 1 | 7.60 |
| CHEMBL160994 | — | — | 1 | 7.51 |
| CHEMBL350819 | — | — | 1 | 7.40 |
| CHEMBL162251 | — | — | 1 | 7.29 |
| CHEMBL158908 | — | — | 1 | 6.72 |
| CHEMBL124071 | — | — | 1 | 6.68 |
| CHEMBL158907 | — | — | 1 | 6.58 |
| CHEMBL161674 | — | — | 1 | 6.16 |
| CHEMBL159055 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158974 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL421843 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL419779 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL351410 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL158384 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL274420 | CV-6209 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL161096 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL160995 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL161597 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL157989 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL290840 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL161127 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL160994 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL350819 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL162251 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL158908 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL124071 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL158907 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL161674 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL159055 | — | IC50 | = | 2800.0 | nM | 5.55 |