Assay Detail
Functional
CHEMBL772389
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Concentration required to decrease [3H]thymidine incorporation by 50 percent in RWLeu4 CML cell line as compared to untreated cells was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RWLeu4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Metabolism and biological activity of 1,25(OH)2D2 and its metabolites in a chronic myelogenous leukemia cell line, rwleu-4
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.87 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3351073 | — | — | 1 | 8.22 |
| CHEMBL56686 | — | — | 1 | 8.10 |
| CHEMBL417751 | — | — | 1 | 7.96 |
| CHEMBL293283 | — | — | 1 | 7.96 |
| CHEMBL3351075 | — | — | 1 | 7.96 |
| CHEMBL3351074 | — | — | 1 | 7.89 |
| CHEMBL3351072 | — | — | 1 | 7.02 |
| CHEMBL3351076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3351073 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL56686 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL417751 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL293283 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3351075 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3351074 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3351072 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3351076 | — | IC50 | > | 100.0 | nM | - |