Assay Detail
Functional
CHEMBL772416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of post-traslational processing of Ras protein in RAT1 cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27141 | — | — | 1 | 6.30 |
| CHEMBL27486 | — | — | 1 | 6.30 |
| CHEMBL275378 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27141 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL27486 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL275378 | — | IC50 | = | 500.0 | nM | 6.30 |