Assay Detail
Binding
CHEMBL772437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Protein-tyrosine phosphatase 1B
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.62 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87536 | — | — | 1 | 5.37 |
| CHEMBL87189 | — | — | 1 | 4.85 |
| CHEMBL87802 | — | — | 1 | 4.85 |
| CHEMBL87601 | — | — | 1 | 4.75 |
| CHEMBL83293 | — | — | 1 | 4.70 |
| CHEMBL85756 | — | — | 1 | 4.70 |
| CHEMBL314229 | — | — | 1 | 4.66 |
| CHEMBL86966 | — | — | 1 | 4.60 |
| CHEMBL85493 | — | — | 1 | 4.60 |
| CHEMBL84898 | — | — | 1 | 4.55 |
| CHEMBL87768 | — | — | 1 | 4.26 |
| CHEMBL86905 | — | — | 1 | 4.14 |
| CHEMBL314564 | — | — | 1 | 4.04 |
| CHEMBL315361 | — | — | 1 | - |
| CHEMBL83628 | CHROMOCARB | 2.0 | 1 | - |
| CHEMBL87426 | — | — | 1 | - |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87536 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL87189 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL87802 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL87601 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL83293 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL85756 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL314229 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL86966 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL85493 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL84898 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL87768 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL86905 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL314564 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL315361 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL83628 | CHROMOCARB | IC50 | > | 1000000.0 | nM | - |
| CHEMBL87426 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | IC50 | > | 1000000.0 | nM | - |