Assay Detail
Binding
CHEMBL772648
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Inhibition of human recombinant Protein-tyrosine phosphatase 1B.
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 4.97 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140120 | — | — | 2 | 5.50 |
| CHEMBL139393 | — | — | 1 | 5.33 |
| CHEMBL138106 | — | — | 1 | 5.23 |
| CHEMBL424652 | — | — | 1 | 5.14 |
| CHEMBL139196 | — | — | 1 | 5.10 |
| CHEMBL137989 | — | — | 1 | 5.08 |
| CHEMBL342603 | — | — | 1 | 5.06 |
| CHEMBL341947 | — | — | 1 | 5.05 |
| CHEMBL136044 | — | — | 1 | 4.96 |
| CHEMBL139074 | — | — | 1 | 4.96 |
| CHEMBL136867 | — | — | 1 | 4.92 |
| CHEMBL140757 | — | — | 1 | 4.92 |
| CHEMBL138240 | — | — | 1 | 4.92 |
| CHEMBL138951 | — | — | 1 | 4.85 |
| CHEMBL138461 | — | — | 1 | 4.82 |
| CHEMBL344368 | — | — | 1 | 4.80 |
| CHEMBL138277 | — | — | 1 | 4.64 |
| CHEMBL136316 | — | — | 1 | 4.54 |
| CHEMBL138995 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140120 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL139393 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL138106 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL140120 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL424652 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL139196 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL137989 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL342603 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL341947 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL139074 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL136044 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL140757 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL138240 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL136867 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL138951 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL138461 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL344368 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL138277 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL136316 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL138995 | — | Ki | = | 42000.0 | nM | 4.38 |