Assay Detail
Binding
CHEMBL772754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C eta C1a domain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.51 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28205 | — | — | 1 | 5.60 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 5.42 |
| CHEMBL318971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28205 | — | Ki | = | 2489.0 | nM | 5.60 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 3770.0 | nM | 5.42 |
| CHEMBL318971 | — | Ki | > | 10000.0 | nM | - |