Assay Detail
Binding
CHEMBL772765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Prostaglandin G/H synthase 1 in human whole blood (HWB) assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.02 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.80 |
| CHEMBL42485 | DUP-697 | — | 1 | 5.92 |
| CHEMBL296370 | — | — | 1 | 4.54 |
| CHEMBL300710 | — | — | 1 | 4.41 |
| CHEMBL49394 | — | — | 1 | 4.39 |
| CHEMBL45583 | — | — | 1 | 4.08 |
| CHEMBL47540 | — | — | 1 | - |
| CHEMBL46171 | — | — | 1 | - |
| CHEMBL49319 | — | — | 1 | - |
| CHEMBL49918 | — | — | 1 | - |
| CHEMBL48671 | — | — | 1 | - |
| CHEMBL47294 | — | — | 1 | - |
| CHEMBL48073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL42485 | DUP-697 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL296370 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL300710 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL49394 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL45583 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL47540 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL46171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL49319 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL49918 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48671 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL47294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48073 | — | IC50 | > | 100000.0 | nM | - |