Assay Detail
Binding
CHEMBL772766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)
109
Total Activities
109
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 109 | 5.29 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29204 | — | — | 1 | 8.30 |
| CHEMBL26915 | SC-560 | — | 1 | 8.15 |
| CHEMBL30011 | — | — | 1 | 7.75 |
| CHEMBL284914 | — | — | 1 | 7.26 |
| CHEMBL280636 | — | — | 1 | 7.19 |
| CHEMBL29257 | — | — | 1 | 7.10 |
| CHEMBL29840 | — | — | 1 | 6.85 |
| CHEMBL287447 | — | — | 1 | 6.77 |
| CHEMBL28491 | — | — | 1 | 6.39 |
| CHEMBL283086 | — | — | 1 | 6.24 |
| CHEMBL282085 | — | — | 1 | 6.08 |
| CHEMBL29766 | — | — | 1 | 6.08 |
| CHEMBL29133 | — | — | 1 | 6.03 |
| CHEMBL28662 | — | — | 1 | 6.01 |
| CHEMBL282839 | — | — | 1 | 5.92 |
| CHEMBL283178 | — | — | 1 | 5.92 |
| CHEMBL282084 | — | — | 1 | 5.88 |
| CHEMBL29697 | — | — | 1 | 5.76 |
| CHEMBL283497 | — | — | 1 | 5.72 |
| CHEMBL281694 | — | — | 1 | 5.72 |
| CHEMBL29839 | — | — | 1 | 5.59 |
| CHEMBL29472 | — | — | 1 | 5.54 |
| CHEMBL28881 | — | — | 1 | 5.48 |
| CHEMBL29899 | — | — | 1 | 5.42 |
| CHEMBL283177 | — | — | 1 | 5.33 |
| CHEMBL28487 | — | — | 1 | 5.29 |
| CHEMBL433428 | — | — | 1 | 5.24 |
| CHEMBL28913 | — | — | 1 | 5.20 |
| CHEMBL29423 | — | — | 1 | 5.07 |
| CHEMBL27975 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29204 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL26915 | SC-560 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL30011 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL284914 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL280636 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL29257 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL29840 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL287447 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL28491 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL283086 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL29766 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL282085 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL29133 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL28662 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL282839 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL283178 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL282084 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL29697 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL281694 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL283497 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL29839 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL29472 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL28881 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL29899 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL283177 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL28487 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL433428 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL28913 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL29423 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL27975 | — | IC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL287170 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL29424 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL280601 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL281975 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL29469 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL29439 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL29500 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL29887 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL29717 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL282093 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL29923 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL28527 | MAVACOXIB | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL286953 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL283388 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL28801 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL29083 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL418574 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL281978 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL282301 | — | IC50 | = | 31000.0 | nM | 4.51 |