Assay Detail
Functional
CHEMBL772767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of angiotensin II induced contraction in thoracic aortic rings from New Zealand rabbits
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Substituted piperidin-2-one biphenyltetrazoles as angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48602 | — | — | 1 | 9.00 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.80 |
| CHEMBL51001 | — | — | 1 | 8.60 |
| CHEMBL418269 | — | — | 1 | 8.40 |
| CHEMBL51084 | — | — | 1 | 8.30 |
| CHEMBL49207 | — | — | 1 | 8.10 |
| CHEMBL49192 | — | — | 1 | 7.90 |
| CHEMBL48459 | — | — | 1 | 7.90 |
| CHEMBL296731 | — | — | 1 | 7.80 |
| CHEMBL50906 | — | — | 1 | 7.50 |
| CHEMBL299151 | — | — | 1 | 7.50 |
| CHEMBL49262 | — | — | 1 | 7.40 |
| CHEMBL295369 | — | — | 1 | 7.40 |
| CHEMBL51622 | — | — | 1 | 7.00 |
| CHEMBL51078 | — | — | 1 | 7.00 |
| CHEMBL413098 | — | — | 1 | 6.90 |
| CHEMBL52046 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48602 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL191 | LOSARTAN | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL51001 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL418269 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL51084 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL49207 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL49192 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL48459 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL296731 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL50906 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL299151 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL49262 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL295369 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL51622 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL51078 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL413098 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL52046 | — | Kd | = | 158.49 | nM | 6.80 |