Assay Detail

CHEMBL772813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity against HIV-2 protease

ChEMBL ↗

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Target

Human rhinovirus A protease (CHEMBL2857) ↗

Open DB target context

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Human rhinovirus A protease (CHEMBL2857) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human rhinovirus A protease

CHEMBL2857

Anchored from Assay target.

Protein identity Human rhinovirus A protease

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Human rhinovirus A protease (CHEMBL2857) ↗

Type	SINGLE PROTEIN
Organism	Human rhinovirus sp.

Publication

Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.

Skulnick HI, Johnson PD, Aristoff PA, Morris JK, Lovasz KD, Howe WJ, Watenpaugh KD, Janakiraman MN, Anderson DJ, Reischer RJ, Schwartz TM, Banitt LS, Tomich PK, Lynn JC, Horng MM, Chong KT, Hinshaw RR, Dolak LA, Seest EP, Schwende FJ, Rush BD, Howard GM, Toth LN, Wilkinson KR, Romines KR.
J Med Chem (1997) 40 : 1149 -1164
PubMed 9089336 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.49	8.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2062136	—	—	1	8.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2062136	—	Ki	=	3.2	nM	8.49