Assay Detail
Binding
CHEMBL772918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition concentration against cyclooxygenase-1 (COX-1) in human whole blood
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.63 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341320 | — | — | 1 | 5.16 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 4.94 |
| CHEMBL126369 | — | — | 1 | 4.86 |
| CHEMBL127153 | — | — | 1 | 4.78 |
| CHEMBL442767 | — | — | 1 | 4.73 |
| CHEMBL129640 | — | — | 1 | 4.67 |
| CHEMBL127211 | — | — | 1 | 4.65 |
| CHEMBL126303 | — | — | 1 | 4.64 |
| CHEMBL125460 | — | — | 1 | 4.64 |
| CHEMBL338457 | — | — | 1 | 4.45 |
| CHEMBL126991 | — | — | 1 | 4.44 |
| CHEMBL127190 | — | — | 1 | 4.43 |
| CHEMBL127868 | — | — | 1 | 4.41 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 4.00 |
| CHEMBL126392 | — | — | 1 | - |
| CHEMBL129473 | — | — | 1 | - |
| CHEMBL339817 | — | — | 1 | - |
| CHEMBL127125 | — | — | 1 | - |
| CHEMBL126629 | — | — | 1 | - |
| CHEMBL338927 | — | — | 1 | - |
| CHEMBL125682 | — | — | 1 | - |
| CHEMBL126810 | — | — | 1 | - |
| CHEMBL127514 | — | — | 1 | - |
| CHEMBL126244 | — | — | 1 | - |
| CHEMBL265071 | — | — | 1 | - |
| CHEMBL126578 | — | — | 1 | - |
| CHEMBL338705 | — | — | 1 | - |
| CHEMBL127084 | — | — | 1 | - |
| CHEMBL126683 | — | — | 1 | - |
| CHEMBL126404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341320 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL126369 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL127153 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL442767 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL129640 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL127211 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL126303 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL125460 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL338457 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL126991 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL127190 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL127868 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 98800.0 | nM | 4.00 |
| CHEMBL127560 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126979 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420351 | — | IC50 | = | 207000.0 | nM | - |
| CHEMBL339258 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338347 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126392 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129473 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL339817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127125 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126629 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL125682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126810 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127514 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL126244 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL265071 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127084 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126404 | — | IC50 | > | 100000.0 | nM | - |