Assay Detail
Binding
CHEMBL772920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | U-937 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.91 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.52 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.29 |
| CHEMBL330976 | — | — | 1 | - |
| CHEMBL331921 | — | — | 1 | - |
| CHEMBL421259 | — | — | 1 | - |
| CHEMBL120467 | — | — | 1 | - |
| CHEMBL122357 | — | — | 1 | - |
| CHEMBL123700 | — | — | 1 | - |
| CHEMBL332169 | — | — | 1 | - |
| CHEMBL120608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL118 | CELECOXIB | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL330976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL120467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122357 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123700 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL120608 | — | IC50 | > | 10000.0 | nM | - |