Assay Detail
Binding
CHEMBL772923
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Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.43 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43520 | — | — | 1 | 6.46 |
| CHEMBL37414 | — | — | 1 | 6.21 |
| CHEMBL287909 | — | — | 1 | 5.89 |
| CHEMBL287919 | — | — | 1 | 5.80 |
| CHEMBL290739 | — | — | 1 | 5.31 |
| CHEMBL41739 | — | — | 1 | 5.21 |
| CHEMBL43461 | — | — | 1 | 5.20 |
| CHEMBL434014 | — | — | 1 | 5.03 |
| CHEMBL41405 | — | — | 1 | 4.92 |
| CHEMBL289262 | — | — | 1 | 4.89 |
| CHEMBL289731 | — | — | 1 | 4.85 |
| CHEMBL37371 | — | — | 1 | - |
| CHEMBL39013 | — | — | 1 | - |
| CHEMBL35992 | — | — | 1 | - |
| CHEMBL43402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43520 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL37414 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL287909 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL287919 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL290739 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL41739 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL43461 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL434014 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL41405 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL289262 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL289731 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL37371 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL39013 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL35992 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL43402 | — | IC50 | > | 100000.0 | nM | - |