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Assay Detail

CHEMBL772924

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
Palomer A, Cabré F, Pascual J, Campos J, Trujillo MA, Entrena A, Gallo MA, García L, Mauleón D, Espinosa A.
J Med Chem (2002) 45 : 1402 -1411
PubMed 11906281 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 7.11 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6 INDOMETHACIN 4.0 1 8.52
CHEMBL118 CELECOXIB 4.0 1 5.70
CHEMBL122 ROFECOXIB 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6 INDOMETHACIN IC50 = 3.0 nM 8.52
CHEMBL118 CELECOXIB IC50 = 2000.0 nM 5.70
CHEMBL122 ROFECOXIB IC50 > 10000.0 nM -