Assay Detail
Functional
CHEMBL772970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.82 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93899 | — | — | 1 | 8.10 |
| CHEMBL82479 | — | — | 1 | 7.21 |
| CHEMBL328487 | — | — | 1 | 7.14 |
| CHEMBL92863 | — | — | 1 | 7.09 |
| CHEMBL92247 | — | — | 1 | 7.06 |
| CHEMBL304818 | DOCEBENONE | 2.0 | 1 | 7.05 |
| CHEMBL93265 | — | — | 1 | 7.00 |
| CHEMBL93678 | — | — | 1 | 7.00 |
| CHEMBL92933 | — | — | 1 | 6.60 |
| CHEMBL90996 | — | — | 1 | 6.18 |
| CHEMBL92747 | — | — | 1 | 6.08 |
| CHEMBL327426 | — | — | 1 | 5.30 |
| CHEMBL93777 | — | — | 1 | 5.28 |
| CHEMBL92414 | — | — | 1 | 5.16 |
| CHEMBL420994 | — | — | 1 | 5.14 |
| CHEMBL329636 | — | — | 1 | 5.06 |
| CHEMBL92083 | — | — | 1 | 5.06 |
| CHEMBL420251 | — | — | 1 | 5.03 |
| CHEMBL89938 | — | — | 1 | 5.02 |
| CHEMBL91799 | — | — | 1 | 4.22 |
| CHEMBL93150 | — | — | 1 | 4.06 |
| CHEMBL330518 | — | — | 1 | 4.00 |
| CHEMBL327696 | — | — | 1 | 4.00 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93899 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL82479 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL328487 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL92863 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL92247 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL304818 | DOCEBENONE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL93265 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL93678 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL92933 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL90996 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL92747 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL327426 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL93777 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL92414 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL420994 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL329636 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL92083 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL420251 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL89938 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL91799 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL93150 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL330518 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL327696 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | - | nM | - |