Assay Detail
Functional
CHEMBL776393
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Muscarinic potency was measured in rat jejunum
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Jejunum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformational studies of muscarone analogues: X-ray analysis and molecular mechanics calculations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.13 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105198 | — | — | 2 | 7.89 |
| CHEMBL105457 | — | — | 2 | 7.58 |
| CHEMBL320820 | — | — | 2 | 7.55 |
| CHEMBL321136 | — | — | 2 | 7.13 |
| CHEMBL12587 | MUSCARINE | — | 1 | 6.81 |
| CHEMBL105471 | — | — | 1 | 6.81 |
| CHEMBL430655 | — | — | 2 | 6.78 |
| CHEMBL317886 | — | — | 2 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105198 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL105198 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL105457 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL105457 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL320820 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL320820 | — | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL321136 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL321136 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL12587 | MUSCARINE | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL105471 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL430655 | — | EC50 | = | 165.96 | nM | 6.78 |
| CHEMBL430655 | — | EC50 | = | 165.96 | nM | 6.78 |
| CHEMBL317886 | — | EC50 | = | 645.65 | nM | 6.19 |
| CHEMBL317886 | — | EC50 | = | 645.65 | nM | 6.19 |