Assay Detail
Functional
CHEMBL776396
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In vitro calcium antagonist activity was assessed against calcium induced constriction of potassium-depolarized rat aorta
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1491 | AMLODIPINE | 4.0 | 3 | 8.70 |
| CHEMBL300302 | — | — | 1 | 8.60 |
| CHEMBL47909 | — | — | 1 | 8.50 |
| CHEMBL297642 | — | — | 1 | 8.50 |
| CHEMBL45450 | — | — | 1 | 8.40 |
| CHEMBL49548 | — | — | 1 | 8.20 |
| CHEMBL44640 | — | — | 1 | 8.10 |
| CHEMBL49448 | — | — | 1 | 8.00 |
| CHEMBL295913 | — | — | 1 | 8.00 |
| CHEMBL296478 | — | — | 1 | 8.00 |
| CHEMBL49742 | — | — | 1 | 7.90 |
| CHEMBL294958 | — | — | 1 | 7.90 |
| CHEMBL44804 | — | — | 1 | 7.90 |
| CHEMBL49108 | — | — | 1 | 7.90 |
| CHEMBL297828 | — | — | 1 | 7.90 |
| CHEMBL46292 | — | — | 1 | 7.80 |
| CHEMBL297871 | — | — | 1 | 7.80 |
| CHEMBL45191 | — | — | 1 | 7.40 |
| CHEMBL46190 | — | — | 1 | 7.40 |
| CHEMBL297674 | — | — | 1 | 7.20 |
| CHEMBL49709 | — | — | 1 | 7.20 |
| CHEMBL45823 | — | — | 1 | 7.10 |
| CHEMBL49743 | — | — | 1 | 6.90 |
| CHEMBL47547 | — | — | 1 | 6.80 |
| CHEMBL296229 | — | — | 1 | 6.80 |
| CHEMBL295674 | — | — | 1 | 6.40 |
| CHEMBL48141 | — | — | 1 | 6.10 |
| CHEMBL44662 | — | — | 1 | 6.00 |
| CHEMBL49949 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1491 | AMLODIPINE | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL300302 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL47909 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL297642 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL45450 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL49548 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL44640 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL49448 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL295913 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL296478 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL44804 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL297828 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL49108 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL49742 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL294958 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL46292 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL297871 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL46190 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL45191 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL49709 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL297674 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL45823 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL49743 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL296229 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL47547 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL295674 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL48141 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL49949 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL44662 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 1584.89 | nM | 5.80 |