Assay Detail
Functional
CHEMBL777085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency required for stimulation of [35S]GTP gamma-S binding to rat spleen was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrazole derivatives as partial agonists for the nicotinic acid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.96 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573 | NIACIN | 4.0 | 1 | 6.02 |
| CHEMBL428730 | — | — | 1 | 5.65 |
| CHEMBL237788 | — | — | 1 | 5.29 |
| CHEMBL128604 | — | — | 1 | 5.16 |
| CHEMBL128679 | — | — | 1 | 4.67 |
| CHEMBL238002 | — | — | 1 | 4.66 |
| CHEMBL338405 | — | — | 1 | 4.19 |
| CHEMBL247317 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573 | NIACIN | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL428730 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL237788 | — | EC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL128604 | — | EC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL128679 | — | EC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL238002 | — | EC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL338405 | — | EC50 | = | 64600.0 | nM | 4.19 |
| CHEMBL247317 | — | EC50 | = | 86900.0 | nM | 4.06 |