Assay Detail
Functional
CHEMBL779054
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In vitro effective concentration for Ca++ uptake into dorsal root ganglia neurones in culture
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.35 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58719 | — | — | 1 | 7.22 |
| CHEMBL80662 | — | — | 1 | 7.00 |
| CHEMBL309891 | — | — | 1 | 6.96 |
| CHEMBL78616 | — | — | 1 | 6.80 |
| CHEMBL76903 | OLVANIL | 2.0 | 1 | 6.77 |
| CHEMBL80404 | — | — | 1 | 6.54 |
| CHEMBL80637 | — | — | 1 | 6.44 |
| CHEMBL75124 | NONIVAMIDE | 3.0 | 1 | 6.26 |
| CHEMBL79767 | — | — | 1 | 5.38 |
| CHEMBL80199 | — | — | 1 | 5.34 |
| CHEMBL77231 | — | — | 1 | 5.09 |
| CHEMBL80157 | — | — | 1 | - |
| CHEMBL80692 | — | — | 1 | - |
| CHEMBL75801 | — | — | 1 | - |
| CHEMBL80456 | — | — | 1 | - |
| CHEMBL78533 | — | — | 1 | - |
| CHEMBL75701 | — | — | 1 | - |
| CHEMBL76731 | — | — | 1 | - |
| CHEMBL80495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58719 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL80662 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL309891 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL78616 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL76903 | OLVANIL | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL80404 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL80637 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL75124 | NONIVAMIDE | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL79767 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL80199 | — | EC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL77231 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL80157 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL80692 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL75801 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL80456 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL78533 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL75701 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL76731 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL80495 | — | EC50 | > | 100000.0 | nM | - |