Assay Detail
Functional
CHEMBL779264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its cardiovascular activity in rat heart model. producing a 50% increase (EC50) in CF(coronary flow).
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.84 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441483 | — | — | 1 | 6.40 |
| CHEMBL337110 | — | — | 1 | 6.00 |
| CHEMBL138455 | — | — | 1 | 5.82 |
| CHEMBL62487 | — | — | 1 | 5.70 |
| CHEMBL87125 | — | — | 1 | 5.60 |
| CHEMBL345052 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441483 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL337110 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL138455 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL62487 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL87125 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL345052 | — | EC50 | = | 3000.0 | nM | 5.52 |