Assay Detail
Functional
CHEMBL779265
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The compound was tested for its cardiovascular activity in rat heart model. producing a 50% increase (EC50) in LV dP/dtmax (measure of contractility).
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.65 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314639 | — | — | 1 | 7.46 |
| CHEMBL345052 | — | — | 1 | 6.38 |
| CHEMBL1203317 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314639 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL345052 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1203317 | — | EC50 | = | 800.0 | nM | 6.10 |