Assay Detail
Functional
CHEMBL779291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cytochrome P450 11B2, mitochondrial (CHEMBL3237) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.57 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 6.22 |
| CHEMBL224060 | VOROZOLE | 2.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL224060 | VOROZOLE | IC50 | = | 12000.0 | nM | 4.92 |