Assay Detail
Functional
CHEMBL779294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of dopamine stimulated production of [14C]-cAMP from [14C]-ATP in homogenates of rat caudate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: halogen and methyl analogues of fenoldopam.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.23 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554009 | — | — | 1 | 6.50 |
| CHEMBL541057 | — | — | 1 | 6.36 |
| CHEMBL542152 | — | — | 1 | 6.22 |
| CHEMBL545000 | — | — | 1 | 6.20 |
| CHEMBL542407 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554009 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL541057 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL542152 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL545000 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL542407 | — | IC50 | = | 1400.0 | nM | 5.85 |