Assay Detail
Functional
CHEMBL779296
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In vitro inhibition of hypoxic-mediated cell injury in Dawley fetal rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.60 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92018 | — | — | 1 | 5.32 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 5.14 |
| CHEMBL91288 | — | — | 1 | 4.29 |
| CHEMBL330049 | — | — | 1 | 4.21 |
| CHEMBL282833 | — | — | 1 | 4.05 |
| CHEMBL94137 | — | — | 1 | - |
| CHEMBL93065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92018 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL91288 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL330049 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL282833 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL94137 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL93065 | — | IC50 | > | 100000.0 | nM | - |