Assay Detail
Functional
CHEMBL779302
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In vitro inhibition of norepinephrine (NE) uptake in crude rat brain synaptosomes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 8.40 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 8.00 |
| CHEMBL55093 | — | — | 1 | 7.75 |
| CHEMBL288524 | — | — | 1 | 7.10 |
| CHEMBL94739 | FEMOXETINE | 2.0 | 1 | 6.39 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 5.92 |
| CHEMBL55822 | — | — | 1 | 4.27 |
| CHEMBL36591 | ALAPROCLATE | 2.0 | 1 | - |
| CHEMBL56675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL295467 | NISOXETINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55093 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL288524 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL94739 | FEMOXETINE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL809 | SERTRALINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL55822 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL36591 | ALAPROCLATE | IC50 | > | 34000.0 | nM | - |
| CHEMBL56675 | — | IC50 | > | 10000.0 | nM | - |