Assay Detail
Functional
CHEMBL779306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of sorbitol accumulation was measured in rat sciatic nerves incubated in the presence of 50 mM glucose at 10e-6 M concentration
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Sciatic nerve |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.55 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 7.43 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL266497 | SORBINIL | IC50 | = | 2200.0 | nM | 5.66 |