Assay Detail
Functional
CHEMBL779502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NMDA-induced depolarizations in rat cortical wedges.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.29 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303539 | — | — | 1 | 7.06 |
| CHEMBL293831 | — | — | 1 | 7.05 |
| CHEMBL450325 | — | — | 1 | 7.05 |
| CHEMBL61364 | — | — | 1 | 6.82 |
| CHEMBL299281 | — | — | 1 | 6.54 |
| CHEMBL59894 | — | — | 1 | 6.46 |
| CHEMBL61720 | — | — | 1 | 6.46 |
| CHEMBL62164 | — | — | 1 | 6.38 |
| CHEMBL58446 | — | — | 1 | 6.19 |
| CHEMBL289832 | LICOSTINEL | 2.0 | 1 | 5.96 |
| CHEMBL58182 | — | — | 1 | 5.96 |
| CHEMBL304436 | — | — | 1 | 5.89 |
| CHEMBL59251 | — | — | 1 | 5.39 |
| CHEMBL283819 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303539 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL293831 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL450325 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL61364 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL299281 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL59894 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL61720 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL62164 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL58446 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL289832 | LICOSTINEL | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL58182 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL304436 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL59251 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL283819 | — | EC50 | = | 16000.0 | nM | 4.80 |