Assay Detail
Functional
CHEMBL779510
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Inhibitory activity against whole cell Ras prenylation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.62 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144536 | — | — | 1 | 8.55 |
| CHEMBL177452 | — | — | 1 | 8.37 |
| CHEMBL344100 | — | — | 1 | 8.36 |
| CHEMBL362186 | — | — | 1 | 7.92 |
| CHEMBL144175 | — | — | 1 | 7.92 |
| CHEMBL367456 | — | — | 1 | 7.28 |
| CHEMBL367324 | — | — | 1 | 6.80 |
| CHEMBL344771 | — | — | 1 | 6.72 |
| CHEMBL175628 | — | — | 1 | 6.70 |
| CHEMBL369548 | — | — | 1 | - |
| CHEMBL177445 | — | — | 1 | - |
| CHEMBL178430 | — | — | 1 | - |
| CHEMBL175682 | — | — | 1 | - |
| CHEMBL177340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144536 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL177452 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL344100 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL362186 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144175 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL367456 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL367324 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL344771 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL175628 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL369548 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL177445 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL178430 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL175682 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL177340 | — | EC50 | > | 1000.0 | nM | - |