Assay Detail
Functional
CHEMBL779558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration measured against U-46,619 (30 nM) induced contraction for rat aorta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor antagonist S-145 and related compounds. 3. Conformation and activity of S-145 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.82 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56941 | — | — | 1 | 8.85 |
| CHEMBL52003 | — | — | 1 | 5.80 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.75 |
| CHEMBL59373 | — | — | 1 | 5.55 |
| CHEMBL418278 | — | — | 1 | 5.34 |
| CHEMBL58772 | — | — | 1 | 5.19 |
| CHEMBL56419 | — | — | 1 | 4.26 |
| CHEMBL56420 | — | — | 1 | - |
| CHEMBL292818 | — | — | 1 | - |
| CHEMBL57196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56941 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL52003 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL59373 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL418278 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL58772 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL56419 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL56420 | — | IC50 | > | 140000.0 | nM | - |
| CHEMBL292818 | — | IC50 | > | 140000.0 | nM | - |
| CHEMBL57196 | — | IC50 | > | 140000.0 | nM | - |