Assay Detail
Functional
CHEMBL779560
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In vitro inhibitory concentration was determined against [45Ca2+]- influx in rat DRG neurons
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.59 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46233 | — | — | 1 | 7.82 |
| CHEMBL48061 | — | — | 1 | 7.70 |
| CHEMBL296963 | — | — | 1 | 7.52 |
| CHEMBL388824 | — | — | 1 | 7.43 |
| CHEMBL48998 | — | — | 1 | 7.22 |
| CHEMBL45252 | — | — | 1 | 7.22 |
| CHEMBL296729 | — | — | 1 | 7.22 |
| CHEMBL43723 | — | — | 1 | 7.18 |
| CHEMBL47282 | — | — | 1 | 7.16 |
| CHEMBL431341 | — | — | 1 | 7.16 |
| CHEMBL228451 | — | — | 1 | 6.96 |
| CHEMBL295773 | — | — | 1 | 6.82 |
| CHEMBL44057 | — | — | 1 | 6.66 |
| CHEMBL45417 | — | — | 1 | 6.60 |
| CHEMBL45455 | — | — | 1 | 6.50 |
| CHEMBL47602 | — | — | 1 | 6.46 |
| CHEMBL48102 | — | — | 1 | 6.30 |
| CHEMBL47473 | — | — | 1 | 6.24 |
| CHEMBL295302 | — | — | 1 | 6.11 |
| CHEMBL47241 | — | — | 1 | 5.96 |
| CHEMBL45050 | — | — | 1 | 5.70 |
| CHEMBL47820 | — | — | 1 | 5.62 |
| CHEMBL48338 | — | — | 1 | 5.52 |
| CHEMBL595069 | IODORESINIFERATOXIN | — | 1 | 5.40 |
| CHEMBL45817 | — | — | 1 | 4.16 |
| CHEMBL391997 | CAPSAZEPINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46233 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL48061 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL296963 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL388824 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL48998 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL45252 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL296729 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL43723 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL47282 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL431341 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL228451 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL295773 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL44057 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL45417 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL45455 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL47602 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL48102 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL47473 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL295302 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL47241 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL45050 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL47820 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL48338 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL595069 | IODORESINIFERATOXIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL45817 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL391997 | CAPSAZEPINE | IC50 | = | 650.0 | nM | - |