Assay Detail
Functional
CHEMBL779569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of galactitol accumulation in sciatic nerves of rat at 5 mg/kg/day
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Sciatic nerve |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | IC50 | = | 1400.0 | nM | 5.85 |