Assay Detail
Functional
CHEMBL779570
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In vivo inhibition of rat osteoclast-mediated bone resorption (BONE RES)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.62 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123262 | — | — | 1 | 8.52 |
| CHEMBL123374 | — | — | 1 | 8.10 |
| CHEMBL122000 | — | — | 1 | 7.34 |
| CHEMBL333019 | — | — | 1 | 6.52 |
| CHEMBL332914 | — | — | 1 | - |
| CHEMBL59562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123262 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL123374 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL122000 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL333019 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL332914 | — | IC50 | - | nM | - | |
| CHEMBL59562 | — | IC50 | - | nM | - |