Assay Detail
Functional
CHEMBL779589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its Cholesterol Synthesis Inhibition ability in rats.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.41 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122112 | — | — | 1 | 7.89 |
| CHEMBL122937 | — | — | 1 | 7.75 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.60 |
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 7.52 |
| CHEMBL333258 | — | — | 1 | 7.50 |
| CHEMBL333933 | — | — | 1 | 7.38 |
| CHEMBL122947 | — | — | 1 | 7.33 |
| CHEMBL123082 | — | — | 1 | 7.30 |
| CHEMBL334113 | — | — | 1 | 6.40 |
| CHEMBL121716 | — | — | 1 | - |
| CHEMBL122965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122112 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL122937 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL54440 | MEVASTATIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL333258 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL333933 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL122947 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL123082 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL334113 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL121716 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL122965 | — | IC50 | > | 1000.0 | nM | - |