Assay Detail
Functional
CHEMBL779591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit [3H]dopamine uptake in rat synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.42 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6368 | p-IODOAMPHETAMINE | — | 1 | 6.23 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.05 |
| CHEMBL6842 | — | — | 1 | 5.73 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 5.51 |
| CHEMBL6330 | — | — | 1 | 4.94 |
| CHEMBL6391 | — | — | 1 | 4.92 |
| CHEMBL6376 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6368 | p-IODOAMPHETAMINE | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL6842 | — | IC50 | = | 1847.0 | nM | 5.73 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 3073.0 | nM | 5.51 |
| CHEMBL6330 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL6391 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL6376 | — | IC50 | = | 28300.0 | nM | 4.55 |