Assay Detail
Functional
CHEMBL779729
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In vitro inhibition of acetylcholine induced phosphatidyl inositol hydrolysis in a rat cerebral cortex slice preparation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Muscarinic antagonist activity of 3-(5-alkoxy-oxazol-2-yl)-1,2,5,6-tetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.86 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | 4.0 | 1 | 8.05 |
| CHEMBL300424 | — | — | 1 | 7.62 |
| CHEMBL295365 | — | — | 1 | 7.50 |
| CHEMBL45694 | — | — | 1 | 7.40 |
| CHEMBL49915 | — | — | 1 | 6.99 |
| CHEMBL298030 | — | — | 1 | 6.67 |
| CHEMBL48342 | — | — | 1 | 6.55 |
| CHEMBL47331 | — | — | 1 | 6.20 |
| CHEMBL296552 | — | — | 1 | 6.19 |
| CHEMBL46324 | — | — | 1 | 6.12 |
| CHEMBL297794 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL300424 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL295365 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL45694 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49915 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL298030 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL48342 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL47331 | — | IC50 | = | 629.0 | nM | 6.20 |
| CHEMBL296552 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL46324 | — | IC50 | = | 752.0 | nM | 6.12 |
| CHEMBL297794 | — | IC50 | = | 758.0 | nM | 6.12 |