Assay Detail
Functional
CHEMBL779964
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Effective Concentration for GH secretion from rat pituitary cell was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.04 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13817 | IBUTAMOREN | 2.0 | 1 | 8.89 |
| CHEMBL105462 | — | — | 1 | 8.00 |
| CHEMBL308716 | — | — | 1 | 7.22 |
| CHEMBL300651 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13817 | IBUTAMOREN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL105462 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308716 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL300651 | — | EC50 | > | 5000.0 | nM | - |