Assay Detail
Functional
CHEMBL779971
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Effective concentration for negative inotropic effect in rat myocardial ventricular strips
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cardiac ventricle |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on Ca2+ channel antagonists. A 2-diazo-3,3,3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.32 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | 2.0 | 2 | 7.66 |
| CHEMBL355473 | — | — | 2 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | EC50 | = | 21.8 | nM | 7.66 |
| CHEMBL51149 | GALLOPAMIL | EC50 | = | 21.8 | nM | 7.66 |
| CHEMBL355473 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL355473 | — | EC50 | = | 105.0 | nM | 6.98 |