Assay Detail
Functional
CHEMBL779977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration of compound was determined for electrophysiological properties on iGluRs using rat cortical slice model in Xenopus laevis oocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.84 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 5.46 |
| CHEMBL73698 | — | — | 1 | 4.66 |
| CHEMBL72366 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL73698 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL72366 | — | EC50 | = | 39000.0 | nM | 4.41 |