Assay Detail
Functional
CHEMBL779978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.55 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161267 | — | — | 1 | 7.89 |
| CHEMBL1161266 | — | — | 1 | 7.89 |
| CHEMBL1161269 | — | — | 1 | 7.85 |
| CHEMBL1161270 | — | — | 1 | 7.72 |
| CHEMBL1161268 | — | — | 1 | 7.72 |
| CHEMBL1161273 | — | — | 1 | 7.60 |
| CHEMBL1161271 | — | — | 1 | 7.47 |
| CHEMBL1161272 | — | — | 1 | 7.09 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161267 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1161266 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1161269 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1161270 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1161268 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1161273 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1161271 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1161272 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 185.0 | nM | 6.73 |