Assay Detail
Functional
CHEMBL779979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes with respect to compound 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.33 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 10.10 |
| CHEMBL1161272 | — | — | 1 | 9.77 |
| CHEMBL1161271 | — | — | 1 | 9.33 |
| CHEMBL1161273 | — | — | 1 | 9.25 |
| CHEMBL1161268 | — | — | 1 | 9.24 |
| CHEMBL1161266 | — | — | 1 | 9.11 |
| CHEMBL1161267 | — | — | 1 | 9.10 |
| CHEMBL1161270 | — | — | 1 | 9.09 |
| CHEMBL1161269 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1161272 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1161271 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1161273 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1161268 | — | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1161266 | — | EC50 | = | 0.77 | nM | 9.11 |
| CHEMBL1161267 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1161270 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1161269 | — | EC50 | = | 1.0 | nM | 9.00 |